BIOVERSE Weight Loss Capsules

The following is an overview of Bioverse Weight Loss Capsules. Please review in its entirety as it contains important safety information and information that will help you get the most out of your treatment.

Bupropion HCl, Naltrexone HCl, and Topiramate are three distinct medications with various therapeutic uses. Bupropion HCl, an aminoketone class antidepressant, is primarily used to treat major depressive disorder (MDD) and seasonal affective disorder (SAD). It also serves as an effective aid in smoking cessation, especially for patients with COPD, and has off-label uses for conditions such as weight loss, ADHD and neuropathic pain. Naltrexone HCl is an opioid antagonist that is primarily indicated for opioid and alcohol use disorder. It is often used off-label for weight loss as well. When bupropion and naltrexone are used together, they work in an area in the brain responsible for appetite regulation which influences eating behaviors. Topiramate is an antiepileptic drug (AED) used to treat various seizure disorders, including partial-onset and generalized tonic-clonic seizures, and is also effective for migraine prevention. In addition to its approved uses, topiramate is employed off-label for conditions like binge-eating disorder, Tourette’s syndrome, and substance abuse disorders, particularly alcohol dependence. These three medications, while distinct in their primary indications, can be used together for effective weight management. Most people can expect about 5-10% weight loss with consistent use for 12 months. Some weight loss is seen as early as 12 weeks.

Dosing Protocols

(Bupropion HCl / Naltrexone HCl / Topiramate) (Each) 65 mg / 8 mg / 15 mg

When you’re ready to start, you will take 1 tablet by mouth daily.  Please keep in mind that medication should be just one part of your weight loss journey. It is important to work on developing healthy eating habits and implementing an exercise routine as well.

Important Safety Information

Buproprion HCl

Seizure Risk: Bupropion is associated with a dose-dependent risk of seizures. This risk is higher in individuals with certain predisposing factors, such as a history of seizures, eating disorders (e.g., bulimia or anorexia nervosa), abrupt discontinuation of alcohol or sedatives, or use of other drugs that lower the seizure threshold.

Neuropsychiatric Symptoms: There is a risk of neuropsychiatric symptoms, including mood changes, depression, and suicidal ideation, particularly in individuals using it for smoking cessation. Close monitoring is recommended.

Hypertension: Bupropion may cause elevated blood pressure, especially when combined with nicotine replacement therapy. Blood pressure should be monitored regularly.

Seizure Disorders: Contraindicated in patients with a history of seizures or conditions that increase the risk of seizures.

Eating Disorders: Contraindicated in patients with bulimia or anorexia nervosa due to the increased risk of seizures.

MAO Inhibitors: Contraindicated in patients currently taking monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing an MAOI due to the risk of hypertensive reactions.

Phentermine HCl

Cardiovascular Risks: Phentermine can cause increases in heart rate and blood pressure and is associated with a risk of serious cardiovascular events, including heart valve disorders and pulmonary hypertension.

Central Nervous System Effects: It may cause nervousness, insomnia, dizziness, and tremors. It can also impair the ability to perform tasks requiring alertness, such as driving.

Potential for Abuse: Phentermine has a potential for abuse and dependence due to its stimulant effects, similar to amphetamines.

Cardiovascular Disease: Contraindicated in patients with a history of cardiovascular disease, including uncontrolled hypertension, coronary artery disease, and arrhythmias.

Hyperthyroidism: Contraindicated in patients with hyperthyroidism due to the risk of exacerbating the condition.

Glaucoma: Contraindicated in patients with glaucoma as it can increase intraocular pressure.

Pregnancy and Breastfeeding: Contraindicated during pregnancy due to potential harm to the fetus and should not be used by breastfeeding mothers.

Topiramate

Cognitive and Psychiatric Effects: Topiramate may cause cognitive impairment, such as difficulties with concentration, memory, and speech. Psychiatric symptoms, including depression and mood changes, may also occur.

Metabolic Acidosis: Topiramate can cause metabolic acidosis, which may result in renal stones or bone demineralization. Regular monitoring of serum bicarbonate levels is recommended.

Hyperammonemia and Encephalopathy: There is a risk of elevated ammonia levels, which can lead to encephalopathy, especially in patients with pre-existing liver disease or those taking valproic acid.

Risks

Accurate Information
Your BIOVERSE team will evaluate the health information you provide to make a treatment recommendation. If you do not provide full and accurate information about your current health and your health history it could lead to failure of a diagnosis or an incorrect diagnosis. This could impact your treatment recommendations. Please contact your provider with any health updates as they come up.

Treatment Failure
This medication is not 100% effective. There is a possibility it may only partially resolve the condition or not work for the condition at all. Should you find the treatment to not be working or you notice new or worsening symptoms or side effects we urge you to reach out to your provider. If there is an emergency situation, call 911 or seek immediate in-person medical attention.

Misdiagnosis or Delayed Diagnosis
As with an in-person doctor, there is a possibility for misdiagnosis or failure to diagnose a condition you may have. This can impact the treatment recommendation from your provider. Our BIOVERSE providers practice using evidence based guidelines to make informed clinical decisions.

Accepting or Declining Our Recommendation
Your healthcare is your decision. Our providers will provide thoughtful evidence based recommendations from the information you provide and the potential benefits and risks associated with the treatment. You should make an evaluation based on our information, relevant input from other providers in your care team and any other important information related to your health to make an informed decision. You are by no means required to follow our recommendation, but keep in mind there can also be risks associated with no treatment.

Alternative Treatment
The recommendation of your BIOVERSE provider is based upon your specific situation, however in some cases there may be alternative treatments available that could work for you. These alternative treatments may vary in how effective they are or require an in-person exam that we are unable to provide. Please message us with any questions or concerns you have regarding your treatment.