Bioverse Weight Loss Capsules

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The following is an overview of Bioverse Weight Loss Capsules. Please review in its entirety as it contains important safety information and information that will help you get the most out of your treatment.

Several medications can be used individually or in combination to support weight management by targeting appetite, metabolism, cravings, and energy balance.

‍Bupropion HCl, an aminoketone antidepressant, reduces food cravings and has been shown to help with weight reduction, particularly when combined with Naltrexone HCl, an opioid antagonist that acts on brain reward pathways involved in eating behaviors. Together, bupropion and naltrexone influence appetite regulation and reward-driven eating, leading to clinically meaningful weight loss.

‍Topiramate, an antiepileptic medication, also contributes to weight reduction by decreasing appetite and altering taste perception. When used in combination with other agents, it can enhance overall outcomes for patients seeking weight loss.

Metformin, a well-established treatment for type 2 diabetes, improves insulin sensitivity and reduces hepatic glucose production. It is often used off-label in individuals with obesity, prediabetes, or polycystic ovary syndrome (PCOS) to support weight loss and metabolic health.

‍Oxytocin, while traditionally known for its role in labor and lactation, has emerging evidence suggesting it may reduce appetite and improve eating control by acting on central pathways related to satiety and reward.

‍Methylcobalamin (Vitamin B12), though not directly associated with weight loss, plays an important supportive role in energy metabolism and neurological function. Optimizing B12 levels can improve energy, reduce fatigue, and support adherence to lifestyle changes required for weight management.

When combined thoughtfully, these medications address multiple drivers of weight gain—including appetite, cravings, metabolic inefficiency, and low energy—making them powerful tools for comprehensive weight management strategies. Clinical results show that consistent use of combinations such as bupropion, naltrexone, and topiramate, often alongside metformin, can achieve 5–10% body weight reduction within 12 months, with benefits often seen as early as 12 weeks.

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Dosing Protocols

(Bupropion HCl / Metformin / Oxytocin / Topiramate / Naltrexone HCl / Methylcobalamin) (Each)
65 mg / 250 mg / 100 IU / 15 mg / 8 mg / 1 mg

When you’re ready to start, you will take 1 tablet by mouth daily.  Please keep in mind that medication should be just one part of your weight loss journey. It is important to work on developing healthy eating habits and implementing an exercise routine as well.

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Important Safety Information

Bupropion HCl

• Seizure Risk: Dose-dependent risk of seizures, higher in individuals with a history of seizures, eating disorders (e.g., bulimia, anorexia), abrupt alcohol or sedative withdrawal, or use of other seizure-threshold–lowering drugs.
• Neuropsychiatric Symptoms: May cause mood changes, depression, or suicidal ideation, especially in smoking cessation use. Monitor closely.
• Hypertension: Can elevate blood pressure, particularly when combined with nicotine replacement. Regular monitoring is recommended.
• Contraindications: Seizure disorders, bulimia or anorexia nervosa, and use with or within 14 days of MAOIs due to hypertensive risk.

Metformin

• Lactic Acidosis: Rare but serious risk, especially in patients with renal impairment, advanced age, liver disease, alcohol abuse, or hypoxic states. Symptoms may include malaise, myalgias, respiratory distress, and abdominal discomfort.
• Gastrointestinal Effects: Common side effects include nausea, vomiting, diarrhea, and abdominal discomfort; starting with a low dose and titrating slowly may help.
• Vitamin B12 Deficiency: Long-term use may lead to B12 deficiency; periodic monitoring is recommended.
• Contraindications: Severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis, or hypersensitivity to metformin.

Oxytocin

• Cardiovascular Risks: May cause hypotension, tachycardia, arrhythmias, and, rarely, cardiovascular collapse with rapid IV administration.
• Uterine Effects: Can cause uterine hyperstimulation, leading to uterine rupture, fetal distress, or postpartum hemorrhage. Careful dosing and continuous monitoring are essential.
• Water Intoxication/Hyponatremia: High doses with excessive fluid intake may lead to water intoxication and seizures.
• Contraindications: Cephalopelvic disproportion, unfavorable fetal position, significant uterine scarring, or situations where vaginal delivery is contraindicated.

Topiramate

• Cognitive and Psychiatric Effects: May impair attention, memory, speech, and cause psychiatric symptoms such as depression and mood changes.
• Metabolic Acidosis: Can reduce serum bicarbonate, potentially leading to renal calculi or bone demineralization; periodic bicarbonate monitoring recommended.
• Hyperammonemia and Encephalopathy: Especially when combined with valproic acid or in patients with liver disease.
  Ophthalmic Effects: May cause acute myopia and secondary angle-closure glaucoma. Discontinue immediately if visual symptoms occur.
• Weight Loss: Frequently associated, which may be undesirable in some patients.

Naltrexone HCl

• Hepatotoxicity: High doses may cause hepatocellular injury. Contraindicated in acute hepatitis or liver failure. Baseline and periodic liver function tests are recommended.
• Opioid Withdrawal Risk: Contraindicated in patients currently dependent on opioids. Must be opioid-free (including tramadol) for 7–10 days before initiation to prevent precipitated withdrawal.
• Injection Site Reactions (for IM formulations): May cause pain, swelling, or rare tissue necrosis.
• Contraindications: Patients receiving opioid analgesics, current physiologic opioid dependence, or acute opioid withdrawal.

Methylcobalamin (Vitamin B12)

• Hypersensitivity Reactions: Rare but possible, including rash, pruritus, and anaphylaxis.
• Hypokalemia: Rapid correction of megaloblastic anemia may cause hypokalemia; monitoring recommended.
• Optic Nerve Atrophy: Use with caution in patients with Leber’s disease, as hereditary optic nerve atrophy can worsen.
• Drug Interactions: Chloramphenicol and high-dose vitamin C may interfere with hematologic response.
• Safety: Generally well tolerated; no known serious toxicity at therapeutic doses.

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Risks

Accurate Information
Your Bioverse team will evaluate the health information you provide to make a treatment recommendation. If you do not provide full and accurate information about your current health and your health history it could lead to failure of a diagnosis or an incorrect diagnosis. This could impact your treatment recommendations. Please contact your provider with any health updates as they come up.

Treatment Failure
This medication is not 100% effective. There is a possibility it may only partially resolve the condition or not work for the condition at all. Should you find the treatment to not be working or you notice new or worsening symptoms or side effects we urge you to reach out to your provider. If there is an emergency situation, call 911 or seek immediate in-person medical attention.

Misdiagnosis or Delayed Diagnosis
As with an in-person doctor, there is a possibility for misdiagnosis or failure to diagnose a condition you may have. This can impact the treatment recommendation from your provider. Our Bioverse providers practice using evidence based guidelines to make informed clinical decisions.

Accepting or Declining Our Recommendation
Your healthcare is your decision. Our providers will provide thoughtful evidence based recommendations from the information you provide and the potential benefits and risks associated with the treatment. You should make an evaluation based on our information, relevant input from other providers in your care team and any other important information related to your health to make an informed decision. You are by no means required to follow our recommendation, but keep in mind there can also be risks associated with no treatment.

Alternative Treatment
The recommendation of your Bioverse provider is based upon your specific situation, however in some cases there may be alternative treatments available that could work for you. These alternative treatments may vary in how effective they are or require an in-person exam that we are unable to provide. Please message us with any questions or concerns you have regarding your treatment.